Yes, it is recommended that DMSA be given at equal intervals throughout the day. If you are giving 3 doses per day then you will need to stick as close to the 8 hour schedule as possible. This allows the DMSA to pull at a consecutive rate. Some argue that the half life of DMSA is 4 hours so that leaves mercury to settle back into the cells before another dose is given. Everyone seems to have their own theory. I say nobody knows your child like you do. So watch closely, take notes and make necessary adjustments accordingly. I don't think any two people are following the exact same protocol with identical supplementation. Our children are each unique in his/her own way. This holds true even when therapies and treatments are to be considered. What one child may respond to with favorable results the next child may experience a bad reaction. I am sure you will make all the best choices any good mother would make. I mean you must be a really good mom or you would not have persevered to this extent, huh?